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Article

Regulatory effects of ferritin on angiogenesis

6 Jan 2009

Abstract excerpt

Angiogenesis, the synthesis of new blood vessels from preexisting vessels, plays a critical role in normal wound healing and tumor growth. HKa (cleaved high molecular weight kininogen) is an endogenous inhibitor of angiogenesis formed by the cleavage of kininogen on endothelial cells. Ferritin is a protein principally known for its central role in iron storage. Here, we demonstrate that ferritin binds to HKa with...

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PMID: 19126685
DOI: 10.1073/pnas.0812010106

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