Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls.

doi:10.1158/1055-9965.EPI-08-0416

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Article

Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2009

Fletcher Olivia, Johnson Nichola, Dos Santos Silva Isabel, Kilpivaara Outi, Aittomäki Kristiina, Blomqvist Carl, Nevanlinna Heli, Wasielewski Marijke, Meijers-Heijerboer Hanne, Broeks Annegien, Schmidt Marjanka K, Van't Veer Laura J, Bremer Michael, Dörk Thilo, Chekmariova Elena V, Sokolenko Anna P, Imyanitov Evgeny N, Hamann Ute, Rashid Muhammad U, Brauch Hiltrud, Justenhoven Christina, Ashworth Alan, Peto Julian

Abstract excerpt

If breast cancers arise independently in each breast the odds ratio (OR) for bilateral breast cancer for carriers of CHEK2 1100delC should be approximately 5.5, the square of the reported OR for a first primary (OR, 2.34). In the subset of bilateral cases with one or more affected relatives, the...

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PMID: 19124502
DOI: 10.1158/1055-9965.EPI-08-0416
PMCID: PMC2727696

Genes

CHEK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19124502-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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