Article
High prevalence of Plasmodium falciparum Pfmdr1 86Y mutant gene in sickle cell disease in Nigeria.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 1 Oct 2008
Agbonlahor Denis Edo, Mirabeau Tatfeng Youtchou, Faith Oviasogie, Inoigbe Omolu Patricia, Samuel Tchouga Kemajou, Clarence Yah Suh
Abstract excerpt
BACKGROUND AND PURPOSE: In areas where malaria is endemic, drug prophylaxis is required for people with sickle cell disease. Chloroquine resistance has been associated with the Plasmodium falciparum multidrug resistance 1 (Pfmdr1) mutant gene. This study tested for the Pfmdr1 86Y mutation in P. falciparum isolates from individuals with sickle cell disease and sickle cell trait, who also underwent hemoglobin...
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