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Article

Analysis of the platypus genome suggests a transposon origin for mammalian imprinting

2 Jan 2009

Abstract excerpt

BACKGROUND: Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene expression. Many hypotheses have been advanced to explain why genomic imprinting evolved in mammals, but few have examined how it arose. The host defence hypothesis suggests that imprinting evolved from existing mechanisms within the cell that act to silence foreign DNA elements that insert into the genome. However, the...

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PMID: 19121219
DOI: 10.1186/gb-2009-10-1-r1

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