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Article

Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting

10 Apr 2007

Abstract excerpt

Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (paternally expressed 10) is a retrotransposon-derived imprinted gene that has an essential role for the formation of the placenta of the mouse. Here, we show...

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PMID: 17432937
DOI: 10.1371/journal.pgen.0030055

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