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Article

Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia.

American journal of human genetics - 1 Jan 2009

Chen Pei-Lung, Avramopoulos Dimitrios, Lasseter Virginia K, McGrath John A, Fallin M Daniele, Liang Kung-Yee, Nestadt Gerald, Feng Ningping, Steel Gary, Cutting Andrew S, Wolyniec Paula, Pulver Ann E, Valle David

Abstract excerpt

Linkage studies have implicated 10q22-q23 as a schizophrenia (SZ) susceptibility locus in Ashkenazi Jewish (AJ) and Han Chinese from Taiwan populations. To further explore our previous linkage signal in the AJ population (NPL score: 4.27, empirical p = 2 x 10(-5)), we performed a peakwide association fine mapping study by using 1414 SNPs across approximately 12.5 Mb in 10q22-q23. We genotyped 1515 AJ individuals,...

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Topics

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Share to Chromosome Mapping
Share to Chromosomes, Human, Pair 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Intracellular Signaling Peptides and Proteins

Share to Neuregulins

Share to Polymorphism, Single Nucleotide

Share to Schizophrenia

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 19118813
DOI: 10.1016/j.ajhg.2008.12.005
PMCID: PMC2668048

Genes

NRG3
NPL
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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