Article
Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air.
Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009
Van Hoeven Neal, Pappas Claudia, Belser Jessica A, Maines Taronna R, Zeng Hui, García-Sastre Adolfo, Sasisekharan Ram, Katz Jacqueline M, Tumpey Terrence M
Abstract excerpt
The influenza virus genes that confer efficient transmission of epidemic and pandemic strains in humans have not been identified. The rapid spread and severe disease caused by the 1918 influenza pandemic virus makes it an ideal virus to study the transmissibility of potentially pandemic influenza strains. Here, we used a series of human 1918-avian H1N1 influenza reassortant viruses to identify the genetic...
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