Evaluation of environmental and personal susceptibility characteristics that modify genetic risks.

Abstract excerpt

Study design in understanding gene-environment interaction plays a crucial role. Different study designs with their advantages and limitations are described in this chapter. Gene penetrance has been studied in several cancers, including breast and prostate cancer. Compared with high-penetrance genes, such as breast cancer (BRCA)1, BRCA2 in breast cancer, gene-environment interaction plays a major role in cancer...

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