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Article

Inhibition of the Bcl-x <sub>L</sub> Deamidation Pathway in Myeloproliferative Disorders

24 Dec 2008

Abstract excerpt

BACKGROUND: The myeloproliferative disorders are clonal disorders with frequent somatic gain-of-function alterations affecting tyrosine kinases. In these diseases, there is an increase in DNA damage and a risk of progression to acute leukemia. The molecular mechanisms in myeloproliferative disorders that prevent apoptosis induced by damaged DNA are obscure. METHODS: We searched for abnormalities of the...

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Share to Acute Myeloid Leukemia Research
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PMID: 19109573
DOI: 10.1056/nejmoa0804953

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