Article
CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy.
Haematologica - 1 Feb 2009
Fischer Lars, Gökbuget Nicola, Schwartz Stefan, Burmeister Thomas, Rieder Harald, Brüggemann Monika, Hoelzer Dieter, Thiel Eckhard
Abstract excerpt
BACKGROUND: Expression of CD56 has been associated with poor prognosis in acute myeloid leukemia and aggressive lymphoma. DESIGN AND METHODS: We analyzed the impact of CD56 expression in a cohort of 452 newly diagnosed adult T-cell acute lymphoblastic leukemia (T-ALL) patients; clinical data were available for 306 patients. Treatment was according to the GMALL study protocols 06/99 and 07/03 stipulating...
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