Article
Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan.
Journal of gastroenterology - 1 Jan 2008
Takahama Yuka, Uto Hirofumi, Kanmura Shuji, Oketani Makoto, Ido Akio, Kusumoto Kazunori, Hasuike Satoru, Nagata Kenji, Hayashi Katsuhiro, Stuver Sherri, Okayama Akihiko, Tsubouchi Hirohito
Abstract excerpt
BACKGROUND: The clinical course of chronic hepatitis C virus (HCV) infection is strongly associated with insulin resistance and obesity. The K121Q polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 gene and the rs7566605 genotype located near insulin-induced gene 2 have been shown to be associated with insulin resistance and obesity. This study examined whether the K121Q polymorphism in...
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