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Article

Label-free detection of DNA mutations by SPR: application to the early detection of inherited breast cancer.

Analytical and bioanalytical chemistry - 1 Feb 2009

Carrascosa L G, Calle A, Lechuga L M

Abstract excerpt

A screening analysis of DNA hybridization and the presence of DNA mutations using an surface plasmon resonance (SPR) biosensor is shown. The influence of lateral and vertical spacers, as well as several hybridization conditions, was studied to optimize the differentiation between fully complementary and mismatched DNA strands. Our results demonstrated that SPR biosensors were able to detect mismatch sequences...

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PMID: 19104783
DOI: 10.1007/s00216-008-2555-1

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SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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