Article
Peptide nucleic acids and biosensor technology for real-time detection of the cystic fibrosis W1282X mutation by surface plasmon resonance.
Laboratory investigation; a journal of technical methods and pathology - 1 Oct 2001
Feriotto G, Corradini R, Sforza S, Bianchi N, Mischiati C, Marchelli R, Gambari R
Abstract excerpt
In this paper we demonstrate that peptide nucleic acids (PNAs) are excellent probes able to detect the W1282X point mutation of the cystic fibrosis (CF) gene when biospecific interaction analysis (BIA) by surface plasmon resonance (SPR) and biosensor technologies is performed. The results reported here suggest that BIA is an easy, fast, and automatable approach for detecting mutations of CF, allowing real-time...
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