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Article

Ischemia- reperfusion Injury and Its Influence on the Epigenetic Modification of the Donor Kidney Genome

15 Dec 2008

Abstract excerpt

BACKGROUND: In clinical transplantation, ischemia-reperfusion injury (I/RI) causes damage to DNA. We hypothesize that one form of damage is the demethylation of methylated cytosines in the donor genome caused by the oxidative environment created first by ischemia, and subsequently by reperfusion on transplantation. This study contributes to the understanding of how the short-lived and transient ischemic insult...

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Share to Epigenetics and DNA Methylation
Share to Organ Transplantation Techniques and Outcomes
Share to Renal Transplantation Outcomes and Treatments

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PMID: 19104428
DOI: 10.1097/tp.0b013e31818fe8f9

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