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Article

Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy.

Experimental eye research - 1 May 2009

Abdelmaksoud Heba E, Yau Edwin H, Zuker Michael, Sullivan Jack M

Abstract excerpt

To identify lead candidate allele-independent hammerhead ribozymes (hhRz) for the treatment of autosomal dominant mutations in the human rod opsin (RHO) gene, we tested a series of hhRzs for potential to significantly knockdown human RHO gene expression in a human cell expression system. Multiple...

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Source

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Identifiers

PMID: 19094986
DOI: 10.1016/j.exer.2008.11.018
PMCID: PMC3388947

Genes

RHO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19094986-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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