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Article

Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells

16 Dec 2008

Abstract excerpt

The recently described hepatic cell line HepaRG is the sole hepatoma cell line susceptible to hepatitis B virus (HBV) infection. It provides a unique tool for investigating some unresolved issues of the virus' biology, particularly the formation of the viral mini-chromosome believed to be responsible for the persistence of infection. In this study, we characterized the main features of HBV infection: it is...

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PMID: 19088281
DOI: 10.1099/vir.0.004861-0

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