Article
Accurate, scalable and integrative haplotype estimation.
Nature communications - 28 Nov 2019
Delaneau Olivier, Zagury Jean-François, Robinson Matthew R, Marchini Jonathan L, Dermitzakis Emmanouil T
Abstract excerpt
The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing datasets. It notably exhibits sub-linear running times with sample size, provides highly accurate...
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