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Article

Linkage analysis of schizophrenia controlling for population substructure.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2009

Paunio Tiina, Arajärvi Ritva, Terwilliger Joseph D, Hiekkalinna Tero, Haimi Perttu, Partonen Timo, Lönnqvist Jouko, Peltonen Leena, Varilo Teppo

Abstract excerpt

Etiological heterogeneity and complexity has hampered attempts to identify predisposing genes for schizophrenia. We sought to minimize the number of segregating genes involved by focusing on a population isolate with elevated disease prevalence. We exploited the well-established population history, and searched for disease susceptibility loci in families from two alternative founder lineages. We studied 28...

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PMID: 19086037
DOI: 10.1002/ajmg.b.30905
PMCID: PMC2861849

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