Article
Decreased expression of the chemokine CCL21 in human colorectal adenocarcinomas.
Oncology reports - 1 Jan 2009
Mumtaz Melad, Wågsäter Dick, Löfgren Sture, Hugander Anders, Zar Niklas, Dimberg Jan
Abstract excerpt
Recent studies have revealed participation of chemokines in cancer by regulating leukocyte movement to modify local immunoresponse. The chemokine CCL21 has been identified to play a pivotal role in homing and localization of immune cells to lymphoid tissue and into organ of non-lymphoid origin. In the cancer biology CCL21 seems to have multifaceted roles. CCL21 attracts CCR7 bearing cells especially T and...
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