Article
Biomarkers in amyotrophic lateral sclerosis.
The Lancet. Neurology - 1 Jan 2009
Turner Martin R, Kiernan Matthew C, Leigh P Nigel, Talbot Kevin
Abstract excerpt
Amyotrophic lateral sclerosis (ALS; motor neuron disease) is a relentlessly progressive disorder. After half a century of trials, only one drug with modest disease-modifying potency--riluzole--has been developed. The diagnosis of this disorder is still clinical and there is a pronounced delay between the onset of symptoms and diagnosis, possibly beyond the therapeutic window. Bedside quantification of the...
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