Article
The impact of interleukin 12B (1188A>C), interleukin 16 (-295T>C), and interleukin 18 (607C>A, 137G>C) gene polymorphisms on long-term renal transplant function and recipient outcomes.
Transplantation proceedings - 1 Jan 2000
Pawlus J, Sierocka A, Tejchman K, Ziętek Z, Romanowski M, Pawlik A, Sieńko J, Żukowski M, Ciechanowski K, Ostrowski M, Sulikowski T
Abstract excerpt
BACKGROUND: Inflammatory mediators play an important role in kidney graft outcome. The cytokine and chemokine gene polymorphisms are associated with variable production, activity, expression, or ligand-receptor affinity. Genetic variation in the DNA sequence of the interleukin 12B (IL12B), interleukin 16 (IL16), and interleukin 18 (IL18) genes may lead to altered cytokine production and activity. These variations...
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