Article
NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.
Malaria journal - 11 Dec 2008
Greve Bernhard, Hoffmann Peter, Vonthein Reinhard, Kun Jürgen, Lell Bertrand, Mycko Marcin P, Selmaj Krysztof W, Berger Klaus, Weissert Robert, Kremsner Peter G
Abstract excerpt
BACKGROUND: Neutrophil cytosolic factor 1, p47phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the DeltaGT/GTGT ratio) may influence the individual capacity to produce ROI. METHODS:...
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