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Article

Modulation of mutant superoxide dismutase 1 aggregation by co-expression of wild-type enzyme.

Journal of neurochemistry - 1 Feb 2009

Prudencio Mercedes, Durazo Armando, Whitelegge Julian P, Borchelt David R

Abstract excerpt

Mutations in superoxide dismutase 1 (SOD1, EC 1.15.1.1) cause familial amyotrophic lateral sclerosis; with aggregated forms of mutant protein accumulating in spinal cord tissues of transgenic mouse models and human patients. Mice over-expressing wild-type human SOD1 (WT hSOD1) do not develop amyotrophic lateral sclerosis-like disease, but co-expression of WT enzyme at high levels with mutant SOD1 accelerates the...

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Identifiers

PMID: 19077113
DOI: 10.1111/j.1471-4159.2008.05839.x
PMCID: PMC2801375

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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