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Differences in nitrate reduction between Mycobacterium tuberculosis and Mycobacterium bovis are due to differential expression of both narGHJI and narK2

8 Dec 2008

Abstract excerpt

Both Mycobacterium tuberculosis and Mycobacterium bovis can produce tuberculosis in humans. Mycobacterium tuberculosis has low nitrate reductase activity during aerobic growth (AG), but shows strong hypoxic induction. Virulent M. bovis has weak activity during AG with no hypoxic induction. Bacille Calmette-Guerin (BCG) lacks activity in both stages. Transcription of narG of the nitrate reductase enzyme operon was...

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PMID: 19076631
DOI: 10.1111/j.1574-6968.2008.01424.x

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