Article
Mycobacterium bovis BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy.
Infection and immunity - 1 Jun 2008
Honaker Ryan W, Stewart Amanda, Schittone Stephanie, Izzo Angelo, Klein Michèl R, Voskuil Martin I
Abstract excerpt
Mycobacterium tuberculosis is the causative agent of tuberculosis, a disease that affects one-third of the world's population. The sole extant vaccine for tuberculosis is the live attenuated Mycobacterium bovis bacillus Calmette-Guerin (BCG). We examined 13 representative BCG strains from around the world to ascertain their ability to express DosR-regulated dormancy antigens. These are known to be recognized by T...
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