Article
The roles of the nitrate reductase NarGHJI, the nitrite reductase NirBD and the response regulator GlnR in nitrate assimilation of Mycobacterium tuberculosis.
Microbiology (Reading, England) - 1 Apr 2009
Malm Sven, Tiffert Yvonne, Micklinghoff Julia, Schultze Sonja, Joost Insa, Weber Isabel, Horst Sarah, Ackermann Birgit, Schmidt Mascha, Wohlleben Wolfgang, Ehlers Stefan, Geffers Robert, Reuther Jens, Bange Franz-Christoph
Abstract excerpt
Mycobacterium tuberculosis can utilize various nutrients including nitrate as a source of nitrogen. Assimilation of nitrate requires the reduction of nitrate via nitrite to ammonium, which is then incorporated into metabolic pathways. This study was undertaken to define the molecular mechanism of nitrate assimilation in M. tuberculosis. Homologues to a narGHJI-encoded nitrate reductase and a nirBD-encoded nitrite...
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