Article
[Association of single nucleotide polymorphisms of Axis inhibitor-2 gene rs224030, rs8081536, rs9913621 with Hirschsprung disease].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 2008
Gao Hong, Zhang Juan, Wang Weilin, Zhang Zhibo, Huang Ying, Zhang Shucheng
Abstract excerpt
OBJECTIVE: To investigate the association of Axis inhibitor-2 (AXIN2) gene rs2240308, rs8081536 and rs9913621 single nucleotide polymorphisms (SNPs) with Hirschsprung disease(HSCR). METHODS: DNA was extracted from 120 HSCR patients and 120 healthy controls. The AXIN2 gene exon2-rs2240308, exon5- rs8081536 and exon6- were amplified by polymerase chain reaction (PCR). SNPs of AXIN2 gene were analyzed by...