Article
Association of Neuregulin 1 rs7835688 G > C, rs16879552 T > C and rs2439302 G > C Polymorphisms with Susceptibility to Non-Syndromic Hirschsprung's Disease.
Fetal and pediatric pathology - 1 Jun 2021
Hosseini-Jangjou Seyed Hamed, Dastgheib Seyed Alireza, Aflatoonian Majid, Amooee Abdolhamid, Bahrami Reza, Salehi Elham, Sadeghizadeh-Yazdi Jalal, Neamatzadeh Hossein
Abstract excerpt
BACKGROUND: Hirschsprung's disease (HSCR) is a heterogeneous congenital malformation of the enteric nervous system with a complex genetic etiology. We investigated if there was an association between Neuregulin-1 (NRG1) rs7835688 G > C, rs16879552 T > C and rs2439302 G > C polymorphisms and the risk of HSCR. Methods: We determined and compared the frequency of NRG1 polymorphisms rs7835688 G > C, rs16879552 T > C...