Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes.

doi:10.1002/humu.20927

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Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes.

Human mutation - 1 Feb 2009

Bleeker Fonnet E, Lamba Simona, Rodolfo Monica, Scarpa Aldo, Leenstra Sieger, Vandertop W Peter, Bardelli Alberto

Abstract excerpt

A recent systematic analysis of 18.191 well annotated coding sequences (RefSeq) in breast and colorectal cancers has led to the identification of somatic mutations in 1.718 genes (Wood et al., 2007). Based on statistical parameters 280 of these have been denominated candidate cancer (CAN) genes. This analysis has provided an interesting snapshot of the landscape of tumor genomes by showing that they contain a few...

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