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Article

Mechanism and active site residues of GDP-fucose synthase.

Journal of the American Chemical Society - 24 Dec 2008

Lau Stephen T B, Tanner Martin E

Abstract excerpt

L-fucose, 6-deoxy-L-galactose, is a key component of many important glycoconjugates including the blood group antigens and the Lewis(X) ligands. The biosynthesis of GDP-L-fucose begins with the action of a dehydratase that converts GDP-D-mannose into GDP-4-keto-6-deoxy-mannose. The enzyme GDP-fucose synthase, GFS, (also known as GDP-4-keto-6-deoxy-D-mannose epimerase/reductase, GMER) then converts...

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PMID: 19053199
DOI: 10.1021/ja807799k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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