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Article

Mechanistic characterization of UDP-glucuronic acid 4-epimerase.

The FEBS journal - 1 Feb 2021

Borg Annika J E, Dennig Alexander, Weber Hansjörg, Nidetzky Bernd

Abstract excerpt

UDP-glucuronic acid (UDP-GlcA) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Despite the different reactions catalyzed, the enzymes are believed to share mechanistic analogy rooted in their joint membership to the short-chain dehydrogenase/reductase (SDR) protein...

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PMID: 32645249
DOI: 10.1111/febs.15478
PMCID: PMC7984243

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