Distinctive expression and function of four <i>GSDM</i> family genes (<i>GSDMA‐D</i>) in normal and malignant upper gastrointestinal epithelium

Abstract excerpt

Gasdermin (GSDM or GSDMA), expressed in the upper gastrointestinal tract but frequently silenced in gastric cancers (GCs), regulates apoptosis of the gastric epithelium. It has three human homologs, GSDMB, GSDMC, and GSDMD (GSDM family) and they are considered to be involved in the regulation of epithelial apoptosis but not yet known. We investigated the expression pattern of the family genes in the upper...

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