Article
Genetic impact of a butyrophilin-like 2 (BTNL2) gene variation on specific IgE responsiveness to Dermatophagoides farinae (Der f) in Japanese.
Allergology international : official journal of the Japanese Society of Allergology - 1 Mar 2009
Konno Satoshi, Takahashi Daisuke, Hizawa Nobuyuki, Hattori Takeshi, Takahashi Ayumu, Isada Akira, Maeda Yukiko, Huang Shau-Ku, Nishimura Masaharu
Abstract excerpt
BACKGROUND: Dermatophagoides farinae (Der f) is one of the most frequently implicated allergens in several allergic diseases. Several genome-wide screens have identified a linkage between chromosome 6p21 and mite-specific IgE responsiveness. Butyrophilin-like 2 (BTNL2) is a member of the immunoglobulin superfamily and, on the basis of its homology to B7-1, has been implicated as a costimulatory molecule involved...
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