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Article

Activation of the <i>Enhancer of Zeste Homologue 2</i> Gene by the Human Papillomavirus E7 Oncoprotein

1 Dec 2008

Abstract excerpt

The malignant phenotype of human papillomavirus (HPV)-positive cancer cells is maintained by the activity of the viral E6 and E7 genes. Here, we identified the polycomb group gene enhancer of zeste homologue 2 (EZH2) as a novel downstream target for the viral oncogenes in HPV-transformed cells. EZH2 expression was activated by HPV16 E7 at the transcriptional level via E7-mediated release of E2F from pocket...

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PMID: 19047178
DOI: 10.1158/0008-5472.can-08-1134

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