Article
The oncogenic potential of hepatitis B virus rtA181T/ surface truncation mutant.
Antiviral therapy - 1 Jan 2008
Lai Ming-Wei, Yeh Chau-Ting
Abstract excerpt
BACKGROUND: Previously, a less prevalent lamivudine-resistant mutant (rtA181T) was discovered in Taiwanese patients, in which a stop codon in the surface gene concomitantly occurred, leading to impaired secretion of hepatitis B virus (HBV) surface antigen. The rtA181T mutant also conferred drug resistance to adefovir. We discovered a 39-year-old patient with advanced hepatocellular carcionoma, who was...
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