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Article

The effect of Ecstasy on memory is moderated by a functional polymorphism in the cathechol-O-methyltransferase (COMT) gene.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Feb 2009

Schilt Thelma, Koeter Maarten W J, de Win Maartje M L, Zinkstok Janneke R, van Amelsvoort Thérèse A, Schmand Ben, den Brink Wim van

Abstract excerpt

There is ample evidence for decreased verbal memory in heavy Ecstasy users. However, findings on the presence of a dose-response relation are inconsistent, possibly due to individual differences in genetic vulnerability. Catechol-O-methyltransferase (COMT) is involved in the catabolism of Ecstasy. Therefore, COMT gene polymorphisms may moderate this vulnerability. We prospectively assessed verbal memory in...

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Source

Identifiers

PMID: 19042106
DOI: 10.1016/j.euroneuro.2008.10.004

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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