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A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics

21 Jul 2025

Abstract excerpt

Physiological changes during pregnancy support foetal growth, including adaptations in pancreatic islets to maintain glucose homeostasis. We investigate these adaptations using rare, high-quality pancreatic tissue from pregnant human donors and matched controls. We profile islets from pregnant donors using proteomics and assess α- and β-cell characteristics, as well as prolactin receptor and serotonin 2B receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40691142
DOI: 10.1038/s41467-025-61852-5

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