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Article

A critical time window of <i>Sry</i> action in gonadal sex determination in mice

26 Nov 2008

Abstract excerpt

In mammals, the Y-linked sex-determining gene Sry cell-autonomously promotes Sertoli cell differentiation from bipotential supporting cell precursors through SRY-box containing gene 9 (Sox9), leading to testis formation. Without Sry action, the supporting cells differentiate into granulosa cells, resulting in ovarian development. However, how Sry acts spatiotemporally to switch supporting cells from the female to...

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PMID: 19036799
DOI: 10.1242/dev.029587

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