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Article

Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway

30 Sept 2004

Abstract excerpt

The endosomal/lysosomal transmembrane protein CLN3 is mutated in the Batten disease (juvenile neuronal ceroid lipofuscinosis, JNCL). However, the molecular mechanism of JNCL pathogenesis and the exact function of the CLN3 protein have remained unclear. Previous studies have shown that deletion of BTN1, the yeast orthologue of CLN3, leads to increased expression of BTN2. BTN2 encodes Btn2p, a proposed homologue to...

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PMID: 15471887
DOI: 10.1093/hmg/ddh321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathwayPMID 15471887Read ↗

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