Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural insights into the inhibited states of the Mer receptor tyrosine kinase.

Journal of structural biology - 1 Feb 2009

Huang Xudong, Finerty Patrick, Walker John R, Butler-Cole Christine, Vedadi Masoud, Schapira Matthieu, Parker Sirlester A, Turk Benjamin E, Thompson Debra A, Dhe-Paganon Sirano

Abstract excerpt

The mammalian ortholog of the retroviral oncogene v-Eyk, and a receptor tyrosine kinase upstream of antiapoptotic and transforming signals, Mer (MerTK) is a mediator of the phagocytic process, being involved in retinal and immune cell clearance and platelet aggregation. Mer knockout mice are viable and are protected from epinephrine-induced pulmonary thromboembolism and ferric chloride-induced thrombosis. Mer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to c-Mer Tyrosine Kinase
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epinephrine

Share to Immune System

Share to Molecular Conformation

Share to Phagocytosis

Share to Receptor Protein-Tyrosine Kinases

Share to Thrombosis

Source

Open in PubMed Open full text

Identifiers

PMID: 19028587
DOI: 10.1016/j.jsb.2008.10.003
PMCID: PMC2686088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural insights into the inhibited states of the Mer receptor tyrosine kinase.PMID 19028587Read ↗

MERTK Inhibition as a Targeted Novel Cancer TherapySemantic proximity Read ↗

A Comprehensive Review of Mutations in the MERTK Proto-Oncogene.Semantic proximity Read ↗

An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action.Semantic proximity Read ↗

MERTK Coordinates Efferocytosis by Regulating Integrin Localization and ActivationSemantic proximity Read ↗

Antagonistic Coevolution of MER Tyrosine Kinase Expression and Function.Semantic proximity Read ↗

Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition.Semantic proximity Read ↗

Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivoSemantic proximity Read ↗

MERTK missense variants in three patients with retinitis pigmentosa.Semantic proximity Read ↗

Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis.Semantic proximity Read ↗

Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis via SYK activationSemantic proximity Read ↗

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.Semantic proximity Read ↗

An ENU-induced mutation in the Mertk gene (Mertknmf12) leads to a slow form of retinal degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.