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Article

Can genetic testing guide treatment in breast cancer?

European journal of cancer (Oxford, England : 1990) - 1 Dec 2008

Tutt Andrew, Ashworth Alan

Abstract excerpt

In the last 15 years, our understanding of genes that predispose to breast cancer has increased enormously. Germline alleles have been identified that have a modest effect on the risk of breast cancer, but there remain only a handful of genes in which mutation substantially elevates the risk of breast cancer. These include BRCA1, BRCA2, TP53 and PTEN. Whilst breast cancer occurring in patients in Li-Fraumeni and...

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Source

Identifiers

PMID: 19027287
DOI: 10.1016/j.ejca.2008.10.009

Genes

BRCA1
BRCA2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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