Article
The analysis of interleukin-1 receptor antagonist and interleukin-1beta gene polymorphisms in Turkish FMF patients: do they predispose to secondary amyloidosis?
Clinical and experimental rheumatology - 1 Jan 2000
Balci-Peynircioğlu B, Taşkiran Z E, Türel B, Arici M, Bakkaloğlu A, Ozen S, Yilmaz E
Abstract excerpt
OBJECTIVE: Amyloid development in familial Mediterranean fever (FMF) patients is associated with acute phase response and the acute phase reactant serum amyloid A which is induced by IL-1Beta. Its concentration can increase to more than 1000 fold during inflammation. In view of the inflammatory nature of FMF disease we have investigated whether IL-1Beta and IL-1 receptor antagonist gene polymorphisms may be...
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