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Article

Synthesis and secretion of a fibrinolytically active tissue-type plasminogen activator variant in Escherichia coli.

Gene - 15 Mar 1991

Waldenström M, Holmgren E, Attersand A, Kalderén C, Löwenadler B, Rådén B, Hansson L, Pohl G

Abstract excerpt

A gene encoding a variant (lacking amino acids 6-173) of human tissue-type plasminogen activator (t-PA), consisting only of the second kringle domain (K2) and the serine protease domain (P), was fused to a DNA segment coding for the signal peptide of staphylococcal protein A and a synthetic gene coding for a protein with ability to bind immunoglobulin G (IgG). The fusion protein which was synthesized in...

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Identifiers

PMID: 1902433
DOI: 10.1016/0378-1119(91)90133-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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