Article
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
Schizophrenia bulletin - 1 Jan 2009
Potkin Steven G, Turner Jessica A, Guffanti Guia, Lakatos Anita, Fallon James H, Nguyen Dana D, Mathalon Daniel, Ford Judith, Lauriello John, Macciardi Fabio
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWASs) are increasingly used to identify risk genes for complex illnesses including schizophrenia. These studies may require thousands of subjects to obtain sufficient power. We present an alternative strategy with increased statistical power over a case-control study that uses brain imaging as a quantitative trait (QT) in the context of a GWAS in schizophrenia....
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