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Article

Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper.

Endocrinology - 1 Apr 2009

Bousquet-Moore D, Ma X M, Nillni E A, Czyzyk T A, Pintar J E, Eipper B A, Mains R E

Abstract excerpt

Amidated peptides are critically involved in many physiological functions. Genetic deletion of peptidylglycine alpha-amidating monooxygenase (PAM), the only enzyme that can synthesize these peptides, is embryonically lethal. The goal of the present study was the identification of physiological functions impaired by haploinsufficiency of PAM. Regulation of the hypothalamic-pituitary-thyroid axis and body...

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Identifiers

PMID: 19022883
DOI: 10.1210/en.2008-1202
PMCID: PMC2659272

Genes

PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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