Article
Robust Bayesian mapping of quantitative trait loci using Student-t distribution for residual.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik - 1 Feb 2009
Wang Xin, Piao Zhongze, Wang Biye, Yang Runqing, Luo Zhixiang
Abstract excerpt
In most quantitative trait loci (QTL) mapping studies, phenotypes are assumed to follow normal distributions. Deviations from this assumption may affect the accuracy of QTL detection, leading to detection of false positive QTL. To improve the robustness of QTL mapping methods, we replace the normal distribution assumption for residuals in a multiple QTL model with a Student-t distribution that is able to...
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