Article
Bayesian robust analysis for genetic architecture of quantitative traits.
Bioinformatics (Oxford, England) - 15 Apr 2009
Yang Runqing, Wang Xin, Li Jian, Deng Hongwen
Abstract excerpt
MOTIVATION: In most quantitative trait locus (QTL) mapping studies, phenotypes are assumed to follow normal distributions. Deviations from this assumption may affect the accuracy of QTL detection and lead to detection of spurious QTLs. To improve the robustness of QTL mapping methods, we replaced the normal distribution for residuals in multiple interacting QTL models with the normal/independent distributions...
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