Article
A splice site mutation converts an inhibitory killer cell Ig-like receptor into an activating one.
Molecular immunology - 1 Feb 2009
Blokhuis Jeroen H, Doxiadis Gaby G M, Bontrop Ronald E
Abstract excerpt
The killer cell Ig-like receptor (KIR) 3DH protein in rhesus macaques (Macaca mulatta) is thought to be an activating one because it contains a charged arginine in its transmembrane domain and has a truncated cytoplasmic domain. MmKIR3DH has thus far been characterized by an analysis of cDNA. Its presence and polymorphism has been further investigated by examining mRNA transcripts and genomic sequences in...
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