Article
Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Dec 2008
Buijtels P C A M, van de Sande W W J, Parkinson S, Petit P L C, van der Sande M A B, van Soolingen D, Verbrugh H A, van Belkum A
Abstract excerpt
Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).
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