Article
Population-specific links between heterozygosity and the rate human microsatellite evolution.
Journal of molecular evolution - 1 Feb 2011
Amos William
Abstract excerpt
Microsatellites form an abundant class of DNA sequences used widely as genetic markers. Surprisingly, the length of human microsatellites varies highly predictably with distance from Africa, apparently following the linear decline in variability that arose as we colonised the world. Such patterns have been used to argue that heterozygosity modulates the rate of microsatellite evolution. Here I test the ensuing...
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